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Pulmonary embolism (PE) is the leading cause of in-hospital demise and the third most frequent trigger of cardiovascular demise. The clinical presentation of PE is variable, and selecting the appropriate remedy for individual patients can be challenging. Traditionally, therapy of PE has concerned a choice of anticoagulation, thrombolysis or surgical procedure; nonetheless, a range of percutaneous interventional technologies have been developed that are underneath investigation in patients with intermediate-excessive-danger or excessive-risk PE. These interventional technologies include catheter-directed thrombolysis (with or without ultrasound assistance), aspiration thrombectomy and combos of the aforementioned ideas. These interventional remedy choices might result in a more rapid enchancment in proper ventricular operate and pulmonary and/or systemic haemodynamics in particular patients.